Comprehensive Genome Analysis of Halolamina pelagica CDK2: Insights into Abiotic Stress Tolerance Genes

Halophilic archaeon Halolamina pelagica CDK2, showcasing plant growth-promoting properties and endurance towards harsh environmental conditions (high salinity, heavy metals, high temperature UV radiation) was sequenced earlier. Pan-genome of genus created investigated for strain-specific genes which might confer it with features helping to withstand abiotic stress. Pathways subsystems in CDK2 were compared other strain CGHMS analysed using KEGG RAST. A genome-scale metabolic model reconstructed from the genome H. CDK2. Results implicated like thermostable carboxypeptidase DNA repair protein MutS protect proteins denaturation respectively. bifunctional trehalose synthase gene responsible biosynthesis also annotated specifying need low salt compatible solute strategy, probable reason behind ability this haloarchaea survive a wide range concentrations. modified shikimate mevalonate pathways identified along many ABC transporters metal uptakes zinc cobalt through pathway analysis. Probable employment one multifunctional transporter place two similar metals (Nickel/cobalt molybdenum/tungsten) be employed as strategy energy conservation. The findings present study could utilized future research relating flux balance analysis genetic repertoire imparting resistance can transferred crops improving their tolerance stresses.